Reproductive Genetics

Reproductive Genetics and Genetic Testing in Karimnagar

How Much Does Genetics Really Matter?

It's estimated that genetic factors are behind roughly 10% of infertility cases and recurrent pregnancy losses, and this risk climbs as a woman gets older, since chromosomal abnormalities become more common with age. Most embryos carrying an incorrect number of chromosomes either fail to implant or end in an early miscarriage. The encouraging part is that modern genetic testing can help identify these issues in advance, meaningfully improving a couple's odds of a successful, ongoing pregnancy.

At Rekha Sagar Fertility Centre, our genetic testing services in Karimnagar are designed to give you clearer answers before, rather than after, an embryo transfer.

PGT-A: Screening for Chromosome Number

Preimplantation Genetic Testing for Aneuploidy (PGT-A) checks embryos, before they're transferred, for an abnormal number of chromosomes. By reviewing every embryo generated during an IVF cycle, we can identify the ones that are chromosomally normal and prioritise them for transfer, which, in turn, helps raise pregnancy rates while lowering the chances of miscarriage.

PGT-M: Testing for Specific Inherited Disorders

PGT-M screens embryos for particular single-gene (monogenic) conditions, such as thalassemia, haemophilia, or certain forms of muscular dystrophy. This is especially valuable for couples with a known family history of these conditions, or who have already had a child affected by one. Only embryos that test clear, or are carriers without being affected, are chosen for transfer, giving families a real chance at a disease-free pregnancy. It can also be combined with PGT-A for even stronger results.

PGT-SR: Checking for Structural Chromosome Issues

For individuals with chromosomal rearrangements, where the genetic material is organised differently than usual, PGT-SR screens embryos for these structural imbalances. Such embryos are often non-viable and can be behind repeated miscarriages, so identifying and avoiding them at the embryo stage can make a meaningful difference.

ERA: Timing the Transfer Precisely

The Endometrial Receptivity Array (ERA) is a personalised test that pinpoints exactly when your uterine lining is most receptive to an embryo, the so-called window of implantation. For some patients, even a good-quality embryo fails to implant simply because the transfer happened a day or two outside this window; ERA helps us avoid that.

Who Should Consider Genetic Testing?

• Couples who've had repeated implantation failure despite good-quality embryos, generally three or more failed transfers for women under 37, or two or more for women over 37
• Patients with a structurally normal uterus and healthy endometrial thickness (6mm or less), where no obvious cause for failure is apparent

A More Informed Path Forward

Genetic testing isn't necessary for every couple, but for those who've faced repeated setbacks or carry a known genetic risk, it can be the missing piece of the puzzle. Our team at Rekha Sagar Fertility Centre in Karimnagar will guide you on whether these tests are relevant to your specific situation, so that every embryo transfer is backed by the clearest possible information.